We then examined the relationship between PDIA5 and 28-immune cell lineage genes in GBM and pan-glioma, and found that the vast majority immune cells, including various types of T cells, B cells, macrophages, myeloid-derived suppressor cells (MDSCs), neutrophils, and natural killer cells, were enriched in the high PDIA5 group of GBM (Figures 4A, B) and pan-glioma (Supplementary Figures S6B, C). Here, PDIA5 is linked to central nervous system cancer.