In CGGA dataset, PDIA5 expression was positively associated with CD276, CD274, PDCD1LG2, and HAVCR2 in pan-glioma and LGG patients, and positively correlated with CD276, PDCD1, CD274, PDCD1LG2, and HAVCR2 in GBM patients. Here, PDIA5 is linked to central nervous system cancer.