To investigate the specific mechanism of PDIA5 overexpression promoting immune infiltration, we further explored the correlation between PDIA5 expression and detailed immune cell types in 33 cancer types, and found that PDIA5 was positively correlated with multiple immune cell infiltrates in most cancers including GBM, LGG, and others (Supplementary Figure S6A). The gene discussed is PDIA5; the disease is cancer.