In contrast, WAKMAR2 overexpression inhibited the proliferation and invasion of RA FLS (Supplementary Figures 2B–D), reduced the levels of PCNA and Cyclin D1 (Supplementary Figure 2E), and decreased the expression and secretion of MMP-3, IL-1, and IL-6 (Supplementary Figures 2F,G). The gene discussed is MMP3; the disease is rheumatoid arthritis.