In the light of these premises, the aims of the present study were to evaluate in PRL- and ACTH-secreting pituitary tumor cell lines the modulation of FLNA phosphorylation by cAMP pathway activation and DRD2 agonist and to study the effects of P-FLNA on DRD2 intracellular signal transduction. The gene discussed is DRD2; the disease is pituitary tumor.