AGT and cardiac hypertrophy: This conclusion is supported by the following evidence: 1) blockade of PI3KC1 promotes Ang II-induced autophagy; in contrast, blockade of PI3KC3 attenuates Ang II-induced autophagy; 2) blockade of PI3KC1 diminishes Ang II-induced increases in mitochondrial ROS production and hypertrophy; 3) blockade of PI3KC3 promotes the Ang II-induced increase in mitochondrial ROS production and hypertrophy; and 4) inhibition of PI3KC1 by viral vector-mediated over-expression of the dominant negative p85 subunit significantly attenuated Ang II-induced cardiac hypertrophy in the heart.