Antidiabetic properties of xenin and dysregulations of neurotensin and pro-neurotensin in obesity and high-fat diet are current areas of interest (Weiss et al., 2001; Wice et al., 2010; Gault et al., 2015; Li et al., 2016; Hasib et al., 2017). Here, NTS is linked to obesity due to melanocortin 4 receptor deficiency.