CASP12 and stroke disorder: Endoplasmic reticulum stress exerts its vital role in stroke-induced neural apoptosis (Mohammed Thangameeran et al., 2020) through activation of downstream CCAATenhancer-binding protein homologous protein (CHOP) and caspase-12 (Chi et al., 2019; Chu et al., 2019; Li Y. et al., 2020).