OPRK1 and urticaria: Lee et al. (2018) found that electroacupuncture (EA) at Hegu (LI4) and Quchi (LI11) acupoints reduced scratching induced by 5’-guanidinonaltrindole [GNTI, a kappa opioid receptor (KOR) antagonist] in mice. Previous clinical and experimental studies have shown that EA can effectively reduce chronic itching caused by psoriasis, atopic dermatitis, urticaria, uremic pruritus, and other chronic allergic skin diseases (Duo, 1987; Che-Yi et al., 2005; Kim et al., 2010; Jung et al., 2014; Wang et al., 2019; Zhang et al., 2020a, b).