MAPT and Alzheimer disease: Many recent studies about AD, mostly indicating LOAD, also reported that there are synergistic or mediated effects between pathological factors (e.g., tau and amyloid, or amyloid and vascular dysregulation) on AD progression (Iturria-Medina et al., 2016; Pascoal et al., 2017; Hanseeuw et al., 2019).