In BrafV600E mice wild-type for Pten (Tyr-Cre:ER Pten+/+ BrafV600E/+), deletion of Atg7 (Tyr-Cre:ER Pten+/+ BrafV600E/+Atg7−/−) significantly accelerated melanoma onset (Fig. 1, Table S1). Here, PTEN is linked to melanoma.