TAL1 and acute lymphoblastic leukemia: We transduced Jurkat and HSB-2, both T-ALL cell lines with aberrant activation of TAL1 (i.e., TAL1 subtype) and intact USP7, with lentivirus of USP7 shRNAs targeting exon 8 (USP7shRNA_4058) and exon 21 (USP7shRNA_4057), which were used in a previous study16, and exon 4 (USP7shRNA_A) (Fig. 3A; Supplementary Table S5), which was designed by our study.