In our study, E2A and HEB protein abundance did not change in Jurkat and Molt-4 cells with partial (50%) USP7 KO (Supplementary Figure S3D, S4D), suggesting that decreased E-protein activity in haploinsufficient USP7 T-ALL cells is unlikely caused by a decrease in E-protein level through a ubiquitin-dependent proteasome degradation. The gene discussed is USP7; the disease is acute lymphoblastic leukemia.