RyR2 mutations can result in severe disease phenotypes, and more than 150 mutations caused catecholaminergic polymorphic ventricular tachycardia (CPVT), and a few have been linked to arrhythmogenic right ventricular cardiomyopathy type 2 and idiopathic ventricular fibrillation19. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.