TFRC and Iron deficiency anemia: In the mouse model, the SK-Mel-28 SNCA-KO melanoma xenografts compensate for the relatively low level of TfR1, which should cause iron deficiency, by decreasing the level of FPN1 (Fig. 7e,f), which decreases the efflux of iron out of cells, and increasing DMT1 (Fig. 7a,d), which, promotes ferrous iron export from endosomes into the cytosol (Fig. 10).