The bioinformatic analysis revealed that ZNF76 rs10947540 was annotated as an eQTL associated with the expression of DEF6. Furthermore, genotyping and expression data from a HapMap population confirmed that the risk allele of rs10947540 was correlated with decreased expression of DEF6. We could not rule out the possibility that rs10947540 might promote the development of SLE by affecting DEF6 expression (supplementary Fig. 1). Here, DEF6 is linked to systemic lupus erythematosus.