Genetic studies have reported that single-nucleotide polymorphisms in zinc finger protein-coding genes are associated with susceptibility to autoimmune diseases, including SNPs in Eos (also known as Ikaros family zinc finger 4; IKZF4) being associated with alopecia areata1, those in zinc finger 432 (ZNF432) with asthma2, those in zinc finger 193 (ZNF 193) with rheumatoid arthritis3, those in zinc finger 365 (ZNF365) isoform D with Crohn's disease4, and those in zinc finger 3 (IKZF3) with Graves’ disease5. The gene discussed is IKZF4; the disease is autoimmune disease.