Strikingly, we found that genetic inhibition of the activity of the Drosophila RhoA ortholog Rho1 by expression of dominant negative Rho1[T19N] rescued both dendritic (Fig. 6i, j) and axonal (Fig. 6k, l) degeneration with expression of neuropathy mutant TRPV4. The gene discussed is TRPV4; the disease is neuropathy.