TRPV4 and neuropathy: Neither pharmacologic inhibition of calcium influx with the specific TRPV4 inhibitor HC067047 (HC067) (Fig. 2b, d) nor a pore-inactivating mutation (M680K)39 (Fig. 2c, e) could restore TRPV4–RhoA binding in neuropathy mutants, indicating that disruption of TRPV4–RhoA interactions with neuropathy mutations occurs independent of ion channel activity.