While WGD occurred in at least one tumour in every patient, it was first observed in the early disease of 5 patients (CAS-E, SK-H, ETH-F, ETH-J, and subclonally in CAS-D), in the regional metastases of CAS-B (subclonally), and not until late disease in 5 patients (CAS-C, CAS-G, MI-F, SK-G, ETH-E). The gene discussed is CSN2; the disease is neoplasm.