Knockdown of LINC00518 expression in WM451 and A375 cells decreased glucose consumption, ATP levels, and lactic acid production in the cells, while overexpression of HIF-1α significantly reversed the effects of LINC00518 silencing of glycolytic tumor metabolism in WM451 and A375 cells (Fig. 6A–C). Here, LINC00518 is linked to neoplasm.