These findings revealed a new oncogenic signal axis,MYC/PNO1/THBS1/FAK/Akt, in the modulation of cell proliferation and metastasis andprovided new insights into how PNO1 works in the progression of glioma.Consequently, interfering in this signal axis could be an efficient way to inhibitglioma development and this is the first report showing the roles and mechanism ofPNO1 as an oncogene in glioma. The gene discussed is AKT1; the disease is central nervous system cancer.