PNO1 and central nervous system cancer: Relevantly, others have proposed that deficient of THBS1 iscritical for MYC-induced metastatic phenotypes inmedulloblastoma.37 Similarly, MYC amplification may play a crucialrole in the angiogenic phenotype through downregulating THBS1 inangiosarcomas.38 All of above results suggest that MYCoverexpression may help drive glioma by triggering PNO1 or THBS1 overexpression.