Thrombospondin1 (THBS1), one of the important components ofextracellular matrix, was first discovered in platelets but has now been involved inregulating tumor development, including glioma.5–7 It has been reported that THBS1 acts as astimulator of focal adhesion kinase (FAK, also known asPTK2).8,9Importantly, a role for FAK activation in GBM cell invasion and migration has beenreported.10 Thus, THBS1 and FAK may serve as the potentialtherapeutic target for GBM. The gene discussed is PTK2; the disease is central nervous system cancer.