It has been demonstrated that MYC regulates transcriptionalamplification by super enhancers, which was a main hallmark ofcancer.34We uncovered that MYC knockdown overtly decreasedexpression levels of PNO1 and THBS1 mRNA and protein in glioma cells, leading to thephosphorylation of FAK and Akt. Here, PNO1 is linked to central nervous system cancer.