THBS1 and central nervous system cancer: It has been demonstrated that MYC regulates transcriptionalamplification by super enhancers, which was a main hallmark ofcancer.34We uncovered that MYC knockdown overtly decreasedexpression levels of PNO1 and THBS1 mRNA and protein in glioma cells, leading to thephosphorylation of FAK and Akt.