Relevantly, others have proposed that deficient of THBS1 iscritical for MYC-induced metastatic phenotypes inmedulloblastoma.37 Similarly, MYC amplification may play a crucialrole in the angiogenic phenotype through downregulating THBS1 inangiosarcomas.38 All of above results suggest that MYCoverexpression may help drive glioma by triggering PNO1 or THBS1 overexpression. The gene discussed is MYC; the disease is glioma.