To further corroborate our conclusion, we knocked down ATG7, another key player in autophagy regulation, and found that decreased ATG7 in SRSF1-downregulated Gefitinib-resistant cancer cells could also partially reverse depleted SRSF1-induced suppression of cancer cell proliferation, thereby promoting cancer cells growth (Supplementary Fig. 7b–e). This evidence concerns the gene SRSF1 and cancer.