SRSF1 and cancer: For instance, the splicing factor SRSF6 is amplified in lung and colon cancers, which can regulate cancer-related RNA splicing to promote cancer progression.25,26 Similarly, SRSF1 is also identified as a proto-oncogene that regulates splicing of important cancer-related genes to promote tumorigenesis.27–29 However, the possible functions and molecular mechanisms of alternative splicing, particularly splicing factors, in autophagy regulation remain largely unknown.