RIPK3 and infection: To assess the role of necroptosis and apoptosis during P. aeruginosa infections, we pre-treated THP-1 macrophages with GSK872 (an inhibitor of RipK3) or z-IETD-FMK (a caspase-8 inhibitor) for 2 h prior to and continued treatment during infections with select clinical isolates from early infections.