IGHE and dermatitis: Although eosinophils were not observed, Th2-type skin inflammation was successfully induced by the EC challenge, as demonstrated by a significant increase in skin thickness (Fig. 5A and B) and serum levels of anti-OVA IgE and IgG1 (Fig. S3), as well as by the upregulation of Il5 and Il13 in the skin of EC-challenged ΔdblGATA mice compared to that in the skin of control ΔdblGATA mice (Fig. S4A).