CHD1L is an important oncoprotein that is overexpressed in various malignant tumors, including HCC [1, 14–18, 21], ovarian cancer [23], gastric cancer [22], colorectal carcinoma [24], bladder cancer [25], breast cancer [4, 26, 63], nasopharyngeal carcinoma [27], glioma [64], NSCLC [12, 66], myeloma [6], pancreatic cancer [65], esophageal carcinoma [28, 67] and cholangiocarcinoma [20, 103] (Fig. 4 and Table 3). This evidence concerns the gene CHD1L and hepatocellular carcinoma.