Overexpression of CHD1L increased the transcription of c-Jun which targeted directly to the promoter of ABCB1 (initially isolated in drug-resistant Chinese hamster ovary cancer cells), and the upregulated ABCB1 phosphoried the NF-κB downstream Iκ-Bα and p65, therefore, CHD1L could induce cisplatin resistance via c-Jun-ABCB1-NF-κB axis in NSCLC [66]. Here, CHD1L is linked to non-small cell lung carcinoma.