Among the control genes that had a significant effect in NPCs were RBM39, which was previously associated with cellular aggregates in yeast [43], as well as MRPL17, encoding for a mitochondrial protein, and the Spinocerebellar Ataxia 10-associated tRNA-processing gene, DTD1. In addition, inhibition of ECM1, which is associated with lipoid proteinosis that may result in epilepsy, neuropsychiatric disorders, and spontaneous CNS hemorrhage, resulted in a significant effect [53]. This evidence concerns the gene ENSG00000280371 and lipoid proteinosis.