SLC2A9 and gout: In the non-gout cohorts, of 30 genetically-independent serum urate-associated genetic variants chosen as having the top effects by GWAS [33] evaluated (Table S2), the SLC2A9 rs12498742 variant was the largest, with PAFs ranging from 28.5 to 32.1% and AAFs from 22.0 to 23.5%.