Since both NHE6 and SCAMP5 are known as the candidate genes for autism, and some of non-sense mutations of NHE6 found in neuropsychiatric disorders fail to associate with SCAMP5 [16], our results suggest an intriguing possibility that defects in NHE6 recruitment into SVs by impaired interaction between NHE6 and SCAMP5 influence the filling of SVs with neurotransmitters, which might underlie the synaptic dysfunction phenotype observed in autism with NHE6 mutations or SCAMP5 reduction. Here, SCAMP5 is linked to autism.