Interestingly, CQDs/Cu2O suppressed migration and angiogenesis processes in vitro mainly through downregulation the expression of VEGFR2 and MMP-2/9, which may be one of the main reasons for the selective inhibition tumor, since angiogenesis is an effective tumor treatment strategy to provide oxygen and nutrients for tumour progression and metastasis. The gene discussed is KDR; the disease is neoplasm.