The Oil-red O-positive glomerular area in AD-ApoE Kyoto group was 9.2% and tended to be higher, compared with that in the other groups [3.9% in AD-ApoE Sendai, 4.8% in AD-apoE3, 2.9% in AD-eGFP, and 3.6%, in ApoE (−/−) groups]. The gene discussed is APOE; the disease is Alzheimer disease.