Anaemia in malaria, however, is associated with a combination of haemolysis of parasitized RBCs, accelerated removal of both parasitized and unparasitized RBCs, depressed and ineffective erythropoiesis due to tumor necrosis factor alpha, anaemia of chronic disease, and splenic phagocytosis or pooling [60–62]. The gene discussed is TNF; the disease is malaria.