In most studies, TMEFF2 has been found to suppress growth [19–21], whereas Nazim Ali and Vera Knauper proposed that shedding of the soluble TMEFF2 ectodomain would induce proliferation by inducing ERK1/2 phosphorylation in an ErbB1-dependent manner in prostate cancer cells [22]. Here, EGFR is linked to prostate carcinoma.