TMEFF2 and central nervous system cancer: To further interrogate the methylation sites of TMEFF2 in glioma, we identified 49 differentially methylated cytosines (DMCs) in a total of 73 CpG sites in the TMEFF2 promoter that were hypermethylated in glioblastoma cells compared to SVG p12 cells (Additional file 1: Table S5, Fig. 1f, g, Additional file 1: Fig S1a–f).