CD274 and cancer: The top 10 KEGG pathways of the nearest genes of Karpas 422 SEs and SUDHL-4 SEs were presented in Fig. 5D. Many of these enrichment pathways, such as “proteoglycans in cancer”, “T cell receptor signaling pathway”, “ErbB signaling pathway” and “PD-L1 expression and PD-1 checkpoint pathway in cancer” were associated with cancer.