Moreover, compared with wildtype adenovirus particles, the infection of mutant ts1 adenovirus particles, which fail to release pVI, to human bone osteosarcoma epithelial cells barely triggers the accumulation of galectin-3 and galectin-8, indicating viral factor pVI contributes to endosomal damage and cytosolic galectin accumulation around damaged endosomes. The gene discussed is LGALS8; the disease is infection.