The current study is designed to improve our understanding of the precise mechanisms of DOX resistance in CRC, we detected the expression of circCSPP1, miR-944, and FZD7 in DOX-resistant CRC tissues and cells, and analyzed the function of circCSPP1 on DOX-resistant CRC cell progression, including proliferation, migration, invasion, and apoptosis. The gene discussed is FZD7; the disease is colorectal carcinoma.