In colorectal cancer, Xiong et al. found that hsa_circ_0007031 and hsa_circ_0000504, promote 5-FU resistance by modulating the miR-885-3p/AKT3 and miR-485-5p/STAT3/AKT3 signaling pathways or by regulating the expression of BCL2 protein [13]. Here, AKT3 is linked to colorectal cancer.