Furthermore, we also found that LC3-II/LC3-I and Beclin1 expression levels were decreased and p62 expression was increased in the GBM-exo group compared with those in the HC-exo group or sh-LINC00470-GBM-exo group (Fig. 3d, P < 0.05), which suggested that exosomes derived from the serum of glioma patients can inhibit cell autophagy while LINC00470 knockdown could abolish GBM-exo induced autophagy inhibition. This evidence concerns the gene LINC00470 and central nervous system cancer.