In addition, the expression levels of p-PI3K/PI3K, p-AKT/AKT and p-mTOR/mTOR in the GBM-exo group were much higher than those in the HC-exo group and sh-LINC00470-GBM-exo group (Fig. 3e, P < 0.05), indicating that serum exosomes from glioma patients could activate the PI3K/AKT/mTOR pathway and LINC00470 could partially offset the activation. This evidence concerns the gene LINC00470 and central nervous system cancer.