Incubation of GBM-exo or transfection with pcDNA3.1-LINC00470 was followed by increases in the expression levels of p-PI3K/PI3K, p-AKT/AKT and p-mTOR/mTOR in U251 and SWO-38 cells compared to the Control group (Fig. 8a–d, P < 0.05). Here, AKT1 is linked to glioblastoma.