AQP1 and diabetic kidney disease: These findings in relation to the increases in AQP-1, − 2, − 4 and − 5 responses are needed further studies to be proven for the involved specific mechanisms such as (i) are they likely compensatory during high cellular and mitochondrial degeneration due to alpha 2u-globulin deposition in the PCTs, (ii) are they associated with an advanced stage of diabetic kidney disease, (iii) are they related to a depletion of glomerular filtration capacity in association with the presence of pedicels disruption and (iv) are they correlated to renal tubule dysfunction, particularly PCTs, DCTs and CD.