INS and acanthosis nigricans: A male newborn with acanthosis nigricans, hirsutism, high insulin levels, and intrauterine growth retardation was compound heterozygous for c.3196C > T (p.R1066*) and c.3614C > T (p.Q1232*) in the tyrosine kinase domain of the β-subunit in INSR [21].