BRAF and non-small cell lung carcinoma: The detection rate of BRAF mutation in ALK rearranged NSCLC is about 0.6%.[17] In addition, one of 27 ALK positive patients who were resistant to ALK-TKIs had a BRAF mutation, according to the literature.[16] The relationship between BRAF mutations and ALK-TKI resistance is not further elucidated in these studies.