Omar et al. determined that AKAP9 acts as a metastasis-promoting gene in SKCM.[45] In addition, as an ROS scavenger in cellular compartments, downregulation of HMOX2 was shown to significantly inhibit tumor growth in lung cancer in vivo.[46] These findings concurred with our results that patients with SKCM had poor prognosis if their cancers were in stage III-IV or in primary sites. This evidence concerns the gene HMOX2 and neoplasm.