In KEGG pathway analysis, these genes were also significantly associated with apoptosis, chronic myeloid leukemia, the ERBB signaling pathway, long term potentiation, the neurotrophin signaling pathway, pancreatic cancer, regulation of actin cytoskeleton, renal cell carcinoma, the Toll-like receptor signaling pathway, and ubiquitin mediated proteolysis (Fig. 12B). The gene discussed is BDNF; the disease is renal cell carcinoma.