CACNA1C and hypertensive disorder: Previous studies have shown that patients with psychiatric disorders, such as bipolar disorder, schizophrenia, or major depression, have a greater risk for hypertension than those without such pathologies.[10]CACNA1C gene rs1006737 polymorphism was reported to be associated with psychiatric disorders.[11–13] It is not yet known whether EH and psychiatric disorders more broadly share biological underpinnings.