In addition, in total of 6 cases have been reported with PRKG2–PDGFRB fusion or t(4;5) translocation.[2–7] Among all the 7 cases, 5 patients were reported to be with peripheral blood basophil proliferation, 4 patients with systemic mast cell hyperplasia, and 6 with mast cell hyperplasia (Table 1). This evidence concerns the gene PRKG2 and mastocytosis.