TNF and obesity due to melanocortin 4 receptor deficiency: Obesity is a multifactorial disease characterized as an abnormal accumulation of adipose tissue in the body, triggering a chronic subclinical state of inflammation.[2] In this condition, adipose tissue is responsible for increasing the secretion of inflammatory mediators, such as Tumor Necrosis Factor alpha (TNF-α) and Interleukin-6 (IL-6) that induce various complications in chronic and metabolic diseases.[3–7]