VEGFA and Varicose veins: Modern pharmacological studies have found that Buyang Huanwu decoction has the effects of inducing angiogenesis, inhibiting cell apoptosis, and protecting nerves.[27–29] It can significantly increase the levels of element binding protein and vascular endothelial growth factor, and significantly reduce inflammation,[30,31] at the same time has the effect of anti-atherosclerosis,[32,33] it can be seen that Buyang Huanwu decoction can play its unique advantages in treating patients with varicose veins of the lower extremities, and has fewer adverse reactions.