Modern pharmacological studies have found that Buyang Huanwu decoction has the effects of inducing angiogenesis, inhibiting cell apoptosis, and protecting nerves.[27–29] It can significantly increase the levels of element binding protein and vascular endothelial growth factor, and significantly reduce inflammation,[30,31] at the same time has the effect of anti-atherosclerosis,[32,33] it can be seen that Buyang Huanwu decoction can play its unique advantages in treating patients with varicose veins of the lower extremities, and has fewer adverse reactions. Here, VEGFA is linked to atherosclerosis.