ACTA2 and cancer: Cluster 0 cells showed fibroblast signatures (RGS5 and NDUFA4L2), cluster 2 cells had strong expression of cancer associated fibroblast (CAF) markers (LUM, SFRP4, and COL1A1), and cluster 5 cells expressed myofibroblast markers (MYH11, TAGLN, and ACTA2).