Activation of the hepatic sirtuins 1-nuclear sterol regulatory element binding protein 1-histone H3 axis has been found to downregulate the expression of genes encoding lipogenic enzymes and to suppress the synthesis of hepatic fatty acids, favoring prevention of high saturated fat against alcoholic fatty liver (You, Cao, Liang, Ajmo, & Ness, 2008). Here, SIRT1 is linked to Hepatic steatosis.