Since ethanol’s effect on a high fat diet in nutrition metabolism and liver injury has not been explored in COX-2 TG mice, we wanted to further elucidate the influence of ethanol in 5 weeks’ exposure time of HF+Eth diet in COX-2 TG mice on weight gain, adipose tissue accumulation, metabolic panel, and inflammatory status. Here, PTGS2 is linked to hydrops fetalis.