While the liver cellular structures of WT mice and TG mice were similar in mice on the regular control diet, HE staining of the liver showed HF+Eth-fed WT mice displayed moderate hepatic steatosis with mild ballooning, while hepatic COX-2 expression protected mice from HF + Eth diet-induced hepatocyte change (Fig. 3A—C). Here, PTGS2 is linked to Hepatic steatosis.