Furthermore, the upregulation of FASN expression in protein and mRNA levels in TG mice on regular and HF+Eth diets prompted us to explore expression levels of SNAIL1 and SIRT1, two relevant regulators that link protein/histone acetylation and energy metabolism (Liu et al., 2018; Rowe et al., 2011; Sekiya & Suzuki, 2011; Sun et al., 2016). The gene discussed is SIRT1; the disease is hydrops fetalis.