STAT3 and keloid: Although additional studies are needed before extrapolating from a representative cell line to keloids writ large, our results add to the growing literature implicating the JAK/STAT3 pathway in the pathogenesis of keloid scars and suggest a possible role for folate metabolism in the pathogenesis of keloid scars and offer pre-clinical data supporting consideration of clinical trials investigating the use of ruxolitinib in keloid disorder.