While a study has reported that decreased expression of SERCA in ASM from asthmatics (who were not genotyped for chromosome 17q12-21 SNPs or enrolled based on history of childhood onset asthma) contributes to airway remodeling (38), we hypothesize that genotyping childhood asthmatics for chromosome 17q12-21 SNPs may identify a subset of asthmatics with increased ORMDL3 and SERCA2b expression. Here, ORMDL3 is linked to asthma.