In contrast to our study demonstrating that ORMDL3 upregulates Ca2+ levels and Orai1 levels in primary mouse ASM cells, studies in a human Jurkat T cell leukemia cell line transfected with ORMDL3 have shown that ORMDL3 negatively modulates SOCE by inhibiting Ca2+ influx and inhibits STIM1 in Jurkat cells (45, 46). The gene discussed is ORAI1; the disease is T-cell leukemia.