PDHA1 mutations cause about 77.2% of all genetically diagnosed cases of PDCD, and the gene has identified more than 190 different mutations through the Human Gene Mutation Database (http://www.hgmd.cf.ac.uk/ac/index.php) and ClinVar database (Patel et al., 2012; Quintana et al., 2009; Sperl et al., 2015). Here, PDHA1 is linked to pre-descemet corneal dystrophy.