LMNA variants have been linked to a class of diseases known as the “laminopathies” that include the accelerated aging diseases (atypical Werner syndrome, restrictive dermopathy, Hutchinson–Gilford progeria syndrome), several muscle diseases (Emery-Dreifuss muscular dystrophy, limb-girdle muscular dystrophy, dilated cardiomyopathy and heart–hand syndrome, congenital muscular dystrophy), peripheral neuropathy (Charcot–Marie-Tooth disease) and the lipodystrophies (Dunnigan-type familial partial lipodystrophy and mandibuloacral dysplasia). This evidence concerns the gene LMNA and lipodystrophy.