TNF and COVID-19: Hence, COVID-19 resembles a hyperimmune syndrome defined by potentially lethal hypercytokinemia due to overproduction of a set of proinflammatory mediators, including interleukins (IL-1β, IL-2, IL7), granulocyte colony stimulating factor, interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-alpha (TNF-α), which culminates in multi-organ failure [8,9].