SERPINE1 and metabolic dysfunction-associated steatotic liver disease: Several other studies in patients with NAFLD/NASH found higher levels of factors VII, VIII, IX, XII, vWF, and tissue factor (TF), as well as increased procoagulant microparticles and platelets aggregation, probably related to higher C-reactive protein, PAI-1, and fibrinogen levels (4,6,8,11,14-17).