FURIN and congestive heart failure: Furin was detected in significantly higher levels in lung homogenates of both compensated CHF rats and decompensated CHF animals compared with sham controls (3.19 ± 0.5; P < .01, 5.1 ± 0.66; P < .001 vs 1.0 ± 0.19, respectively) (Figure 3B).