Analysis of regional furin immunoreactivity in kidney unravelled slight upregulation of cortical furin (1.36 ± 0.12; P < .05), but not in the medulla (0.93 ± 0.12; P = NS) of compensated CHF as compared to sham controls (1.0 ± 0.01) (Figure S1E,F). This evidence concerns the gene FURIN and congestive heart failure.