Perhaps, declining ADAM17 renal expression in CHF preserves abundance of ACE2 in renal tissues despite its internalization and degradation, promoting Ang 1‐7 excess over Ang II in pericytes, as the upregulation of ACE2 in the pulmonary, cardiac and renal tissues may contribute to maintain the integrity of these vital systems in COVID‐19 disease.17, 42, 61. This evidence concerns the gene ADAM17 and congestive heart failure.