ANGPT1 and heart failure: Interestingly, both clinical and experimental heart failure are associated with enhancement of cardiac ACE2 and Ang 1‐7 generation,8, 14, 16, 18, 19, 20, 21, 22 a phenomenon that may represent a counterbalancing compensatory response to Ang‐II‐induced vasoconstriction, cardiac remodelling and sodium retention.