Renal ADAM17 immunoreactivity declined in compensated CHF and decompensated groups in correlation with CHF severity (0.75 ± 0.07; P < .05, 0.54 ± 0.19; P = .07, vs 1.0 ± 0.01, respectively) (Figure 5H,I). This evidence concerns the gene ADAM17 and congestive heart failure.