Similarly, the expression of ADAM‐17 in RV was higher in compensated CHF rats as compared with sham (1.24 ± 0.09 vs 1.0 ± 0.09; P = NS), but significantly lower in decompensated animals (0.56 ± 0.07 vs 1.0 ± 0.09; P < .01) (Figure 5G). The gene discussed is ADAM17; the disease is congestive heart failure.