ACE2 and congestive heart failure: Interestingly, analysis of ACE2 immunoreactivity in the renal cortex and medulla revealed again upregulation in the renal cortical tissue (1.66 ± 0.14 vs 1.0 ± 0.03; P < .01) as well as in the medulla (2.2 ± 0.59 vs 1.0 ± 0.11; P = NS) of compensated CHF as compared to sham controls, but not the decompensated animals (Figure S1C,D).