ADAM17 and congestive heart failure: The expression of ADAM17 in LV was significantly higher in compensated CHF rats as compared with sham (1.47 ± 0.08 vs 1.0 ± 0.08; P < .01), but lower in decompensated animals (0.74 ± 0.2 vs 1.0 ± 0.08; P = NS), (Figure 5E).