In addition, 10 DEGs were identified as predictors of OS of CRC patients through stepwise multivariate Cox regression analysis (Figure 4B) and further utilized for constructing a prognostic risk model (risk score = SPOCK1 × 0.287634‐VIM × ‐0.70744 + C5AR1 × 0.376991 + WWTR1 × 0.204543 + SERPINE1 × 0.164739 + EFEMP1 × 0.085466 + FSCN1 × 0.11085‐FLNA × ‐0.08217‐CXCL8 × 0.18518‐NOX1 × 0.04164). The gene discussed is EFEMP1; the disease is colorectal carcinoma.