Afterwards, a prognostic risk factor model, which classifies CRC patients into low‐ and high‐risk categories in OS and DFS, was constructed according to ten selected EMT‐related prognostic genes (SPOCK1, VIM, C5AR1, WWTR1, SERPINE1, EFEMP1, FSCN1, FLNA, CXCL8, NOX1). This evidence concerns the gene SERPINE1 and colorectal carcinoma.